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KMID : 1134819960250050839
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Journal of the Korean Society of Food Science and Nutrition
1996 Volume.25 No. 5 p.839 ~ p.845
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Effect of Jujube Methanol Extract on the Hepatotoxicity in CCI₄ - Treated Rats
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Na Hyun-Suk
Kim Kyong-Su
Lee Myong-Ryeol
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Abstract
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To investigate effects of Jujube methanol extract on the carbon tetrachloride-induced liver damage in rats, experimental animals were divided into 4 groups; control group(CON), Jujube methanol extracttreated group(JME), CCI₄- treated groups(CCI), and Jujube methanol extract and CCI₄- treated group (JMC). Each group was sacrificed after 2 or 4week feeding and determined the activities of serum transaminase(GOT, GPT) and hepatic xanthine oxidase, superoxide dismutase(SOD), catalase and glutathione peroxidase(GSH-Px), and hepatic contents of thiobarbituric acid-reactants(TBARS) and glutathione in liver. The activities of sGOT and sGPT, and the hepatic content of TBARS after CC1₄-treatment were markedly increased, compared to CON, but those levels were significantly decreased by the pretreatment of Jujube methanol extract, especially in sGOT after 2 and 4 week and TBARS after 4week, respectively. Xanthine oxidase activity was increased by CCI₄- treatment as compared to CON, but it was also inhibited by the pretreatment of Jujube methanol extract for 2 and 4 week. The activities of SOD, catalase and GSH-Px were elevated by CCl₄-treatment, compared to CON, but those elevated activities were showed significant decreasing effect by pretreatment of Jujube methanol extract after 2 and 4week as compared to CON, however, hepatic catalase activity was not affected significantly. These results suggest that Jujube methanol extract is believed to be a possible protective effect for the carbon tetrachloride-induced hepatotoxicity in rats.
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KEYWORD
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Jujube methanol extract, hepatotoxicity, glutathione peroxidase, carbon tetrachloride
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